" /> Gimistotug - CISMeF





Preferred Label : Gimistotug;

NCIt synonyms : Anti-OX40 Agonist Monoclonal Antibody BGB-A445;

NCIt definition : An agonistic monoclonal antibody targeting the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory and antineoplastic activities. Upon administration, gimistotug selectively binds to OX40, thereby activating OX40. This induces the proliferation of memory and effector T-lymphocytes and results in a T-cell-mediated immune response against tumor cells, which leads to tumor cell lysis. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and provides a co-stimulatory signal that promotes both the proliferation and survival of activated T-cells.;

UNII : PT47RQF9HF;

CAS number : 2768487-95-0;

Molecule name : BGB-A445; BGB A445;

NCI Metathesaurus CUI : CL1412805;

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31/05/2025


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