NCIt definition : An agonistic monoclonal antibody targeting the co-stimulatory receptor OX40 (CD134;
tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory
and antineoplastic activities. Upon administration, gimistotug selectively binds to
OX40, thereby activating OX40. This induces the proliferation of memory and effector
T-lymphocytes and results in a T-cell-mediated immune response against tumor cells,
which leads to tumor cell lysis. OX40, a cell surface glycoprotein and member of the
tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes
and provides a co-stimulatory signal that promotes both the proliferation and survival
of activated T-cells.;