Preferred Label : Agonistic Anti-OX40 Monoclonal Antibody INCAGN01949;
NCIt synonyms : Monoclonal Antibody INCAGN01949; Anti-OX40 Agonist Antibody INCAGN01949; Anti-OX40 Monoclonal Antibody INCAGN0194;
NCIt definition : An agonistic human immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the
co-stimulatory receptor OX40 (CD134; TNFRSF4), with potential immunostimulatory and
antineoplastic activities. Upon administration, agonistic anti-OX40 monoclonal antibody
INCAGN01949 selectively binds to and activates OX40 on activated T-cells, thereby
potentiating T-cell receptor (TCR) signaling. OX40 activation inhibits regulatory
T-cell (Treg)-mediated suppression of effector T-cells, induces the proliferation
of memory and effector T-lymphocytes and modulates cytokine production. In the presence
of tumor-associated antigens (TAAs), this may promote an immune response against the
TAA-expressing tumor cells. In addition, the IgG1 Fc region of INCAGN01949 binds to
and co-engages with the IgG Fc-gamma receptor III (FcgammaRIII; CD16) expressed by
immune effector cells; thus, binding activates FcgammaRIII-mediated signaling and
facilitates the selective depletion of intratumoral Tregs, thereby further enhancing
the cytotoxic T-lymphocyte (CTL)-mediated tumor cell response. OX40, a cell surface
glycoprotein and member of the tumor necrosis factor (TNF) receptor superfamily, is
expressed on T-lymphocytes and provides a co-stimulatory signal for the proliferation
and survival of activated T-cells; OX40 stimulation abrogates the immunosuppressive
tumor microenvironment.;
Molecule name : NCAGN01949; INCAGN-1949; INCAGN 1949;
NCI Metathesaurus CUI : CL512862;
Origin ID : C129967;
UMLS CUI : C4331834;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
