" /> Revdofilimab - CISMeF





Preferred Label : Revdofilimab;

NCIt synonyms : Anti-OX40 Agonistic Monoclonal Antibody ABBV-368; Agonistic Anti-OX40 Monoclonal Antibody ABBV-368; Anti-OX40 Agonist Monoclonal Antibody ABBV-368;

NCIt definition : An agonistic humanized IgG1 monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, revdofilimab selectively binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation.;

UNII : 2Y83Y2ORD3;

CAS number : 2230138-89-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2230138-89-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABBV 368; ABBV-368; PR1628103;

NCI Metathesaurus CUI : CL970355;

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15/05/2024


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