NCIt definition : An agonistic monoclonal antibody against the co-stimulatory receptor OX40 (CD134;
TNFRSF4), with potential immunostimulatory activity. Upon administration, anti-OX40
monoclonal antibody BMS 986178 selectively binds to and activates the OX40 receptor,
by mimicking the action of the endogenous OX40 ligand (OX40L). OX40 receptor activation
induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated
antigens (TAAs), this may promote an immune response against the TAA-expressing tumor
cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor
family (TNFRSF), is expressed on T-lymphocytes and provides a co-stimulatory signal
for the proliferation and survival of activated T-cells.;