NCIt definition : A cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus
encoding inactive, mutant forms of the human papillomavirus (HPV) transforming proteins
E6 and E7, with potential immunostimulating and antineoplastic activities. Upon administration
of adenovirus expressing mutant HPV E6/E7, the adenovirus infects and expresses the
E6 and E7 proteins. The expressed E6 and E7 proteins stimulate the host immune system
to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV
E6 and E7, thereby inducing tumor cell lysis. Oncoproteins E6 and E7 play a key role
in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.;
Semantic type(s)