NCIt definition : An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory
activity. Mimicking the natural OX4 ligand (OX40L), anti-OX40 monoclonal antibody
selectively binds to and activates the OX40 receptor. Receptor activation induces
proliferation of memory and effector T lymphocytes. In the presence of tumor associated
antigens (TAAs), this may promote an immune response against the TAA-expressing tumor
cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF)
receptor family, is expressed by CD4 T cells and provides a costimulatory signal for
T cell activation.;