Preferred Label : Interferon-gamma-expressing Adenovirus Vaccine ASN-002;
NCIt synonyms : Ad-IFNg; INFg-expressing Ad Vaccine ASN-002;
NCIt definition : A replication-defective adenoviral serotype 5 vector encoding a recombinant form of
the human cytokine interferon-gamma (IFN-g), with potential antineoplastic and immunoregulatory
activities. Upon intratumoral administration, the sustained expression of IFN-g by
IFN-g-expressing adenovirus vaccine ASN-002 promotes a T-helper type 1 (Th1) immune
response and inhibits the Th2-mediated cytokine production observed in many cutaneous
lymphomas. IFN-g also mediates interleukin-12 (IL-12) production by antigen-presenting
cells (APCs); activates macrophages, cytotoxic T-cells, and natural killer (NK) cells;
upregulates major histocompatibility complex (MHC) molecules; and stimulates antibody-dependent
cellular cytotoxicity (ADCC). Altogether, these IFN-g-mediated effects may result
in both an inhibition of tumor cell proliferation and tumor cell death. Compared to
IFN-g injections, the prolonged local production of IFN-g at the tumor site allows
for higher efficacy and a reduction of systemic toxicity.;
Molecule name : ASN-002; TG1042;
Origin ID : C66972;
UMLS CUI : C4048796;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
