" /> Agonistic Anti-OX40 Monoclonal Antibody MEDI6469 - CISMeF





Preferred Label : Agonistic Anti-OX40 Monoclonal Antibody MEDI6469;

NCIt synonyms : Agonistic Anti-CD134 Monoclonal Antibody MEDI6469;

NCIt related terms : MEDI-6469;

NCIt definition : An agonistic monoclonal antibody against the co-stimulatory receptor OX40 (CD134), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, anti-OX40 monoclonal antibody MEDI6469 selectively binds to and activates OX40. OX40 activation induces proliferation of effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on T-lymphocytes and provides a co-stimulatory signal for the proliferation and survival of activated T-cells.;

UNII : AKV2GM43DD;

CAS number : 1715924-11-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1715924-11-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MEDI6469;

NCI Metathesaurus CUI : CL474118;

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15/05/2024


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