NCIt definition : An agonistic monoclonal antibody against the co-stimulatory receptor OX40 (CD134),
with potential immunostimulatory and antineoplastic activities. Upon intravenous administration,
anti-OX40 monoclonal antibody MEDI6469 selectively binds to and activates OX40. OX40
activation induces proliferation of effector T-lymphocytes. In the presence of tumor-associated
antigens (TAAs), this may promote an immune response against the TAA-expressing tumor
cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF)
receptor superfamily, is expressed on T-lymphocytes and provides a co-stimulatory
signal for the proliferation and survival of activated T-cells.;