NCIt definition : A fully human immunoglobulin G4 (IgG4) agonistic monoclonal antibody targeting CD137
(4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential
immunostimulating and antineoplastic activities. Upon administration, anti-CD137 agonistic
monoclonal antibody CTX-471 binds to and activates CD137 expressed on a variety of
leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells.
This enhances CD137-mediated signaling, induces cytokine production and promotes T-cell
mediated anti-tumor immune responses. CD137, a surface glycoprotein of the tumor necrosis
factor receptor superfamily, is an inducible costimulatory receptor that plays a key
role in T-cell proliferation, survival and cytolytic activity.;