" /> Ivuxolimab - CISMeF





Preferred Label : Ivuxolimab;

NCIt synonyms : PF04518600; Anti-OX40 Agonist Monoclonal Antibody PF-04518600;

NCIt definition : An agonistic antibody that recognizes the co-stimulatory receptor OX40 (CD134; TNFRSF4), with potential immunostimulatory activity. Upon administration, ivuxolimab selectively binds to and activates OX40; which induces proliferation of memory and effector T-lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote a T-cell-mediated immune response against TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation.;

UNII : APS3IS9D6W;

CAS number : 2128729-41-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2128729-41-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PF-04518600; PF-8600;

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15/05/2024


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