Preferred Label : Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L/IL-23/IL-36gamma mRNA-2752;
NCIt synonyms : Lipid Nanoparticle Encapsulated OX40L/IL-23/IL-36gamma mRNAs mRNA-2752; Lipid Nanoparticle Encapsulated mRNAs Encoding Human OX40L/IL-23/IL-36gamma mRNA-2752;
NCIt definition : A lipid nanoparticle encapsulating mRNAs encoding for the human co-stimulatory protein
tumor necrosis factor ligand superfamily member 4 (TNFSF4; OX40 Ligand; OX40L), the
pro-inflammatory cytokines interleukin-23 (IL-23) and interleukin-36gamma (IL-36gamma),
with potential immunomodulatory and anti-tumor activities. Upon intratumoral (IT)
injection of the lipid nanoparticle encapsulated mRNAs encoding human OX40L/IL-23/IL-36gamma
mRNA-2752, the lipid nanoparticle binds to the plasma membrane of cells and releases
the mRNAs into the cell. The OX40L mRNA is then translated by the cellular protein
translation machinery to produce OX40L protein, which is then expressed on the plasma
membrane of the cells that internalized the OX40L mRNA. OX40L binds to and activates
signaling pathways downstream of its cognate receptor tumor necrosis factor receptor
superfamily member 4 (TNFRSF4; OX40), which is expressed on activated T-cells. OX40L/OX40
binding promotes increased cytokine production, which can induce proliferation of
memory and effector T-lymphocytes against the nearby tumor cells. The co-administration
of IL-23 and IL-36gamma further stimulates anti-tumor immune responses. Altogether,
this may enhance T-cell mediated anti-tumor immune responses thereby killing of the
tumor cells. OX40L, a cell surface glycoprotein and member of the tumor necrosis factor
(TNF) ligand superfamily, provides a co-stimulatory signal for the proliferation and
survival of activated T-cells. IL-36gamma activates innate immune cells and promotes
T-helper 1 (Th1) responses, whereas IL-23 has been implicated in Th1/Th17 immunity
as well as in the modulation of antigen-presenting cells (APCs).;
Molecule name : mRNA-2752; mRNA 2752;
NCI Metathesaurus CUI : CL936882;
Origin ID : C157247;
UMLS CUI : C4763507;
Semantic type(s)
- concept_is_in_subset
- has_target
