Preferred Label : Lipid Nanoparticle Encapsulated OX40L mRNA-2416;
NCIt synonyms : Lipid Nanoparticle Encapsulated mRNA Encoding Human OX40L;
NCIt definition : A proprietary formulation consisting of a lipid nanoparticle encapsulating a synthetic
messenger RNA (mRNA) encoding the human co-stimulatory protein tumor necrosis factor
ligand superfamily member 4 (TNFSF4; OX40 Ligand; OX40L), with potential immunomodulatory
and antitumor activities. Although the mechanism of action has not been completely
characterized, following intratumoral injection of lipid nanoparticle encapsulated
OX40L mRNA-2416, the lipid nanoparticle moiety presumably binds to the plasma membrane
of nearby cells and releases the OX40L mRNA into the cell. The OX40L mRNA is then
translated by the cellular protein translation machinery to produce OX40L protein,
which is then expressed on the plasma membrane of the cells that internalized the
OX40L mRNA. OX40L binds to and activates signaling pathways downstream of its cognate
receptor tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40), which
is expressed on activated T-cells. OX40L/OX40 binding promotes increased cytokine
production, which can induce proliferation of memory and effector T-lymphocytes. Altogether,
this may enhance an immune response that promotes the killing of nearby tumor cells.
OX40L, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) ligand
family, provides a co-stimulatory signal for the proliferation and survival of activated
T cells.;
Molecule name : mRNA-2416; mRNA 2416;
NCI Metathesaurus CUI : CL540181;
Origin ID : C142137;
UMLS CUI : C4684440;
Semantic type(s)
- concept_is_in_subset
- has_target
