Soluble Tumor Necrosis Factor Receptor Superfamily Member 8

Preferred Label : Soluble Tumor Necrosis Factor Receptor Superfamily Member 8;

NCIt synonyms : Soluble Ber-H2; Soluble Ki-1 Antigen; Soluble CD30; sCD30; Soluble Ki-1; Soluble CD30L Receptor;

NCIt definition : Soluble tumor necrosis factor receptor superfamily member 8 ( 85 kDa) is encoded by the human TNFRSF8 gene. This enzymatically processed protein may be involved in the inhibition of tumor necrosis factor ligand superfamily member 8 (CD30 ligand) binding to its cell surface-localized receptor.;

NCIt note : Elevated levels of soluble tumor necrosis factor receptor superfamily member 8 may be a marker for tumor burden or graft rejection.; Soluble tumor necrosis factor receptor superfamily member 8 results from proteolytic processing of the full-length membrane-bound tumor necrosis factor receptor superfamily member 8 protein by disintegrin and metalloproteinase domain-containing protein 17. (J Immunol. 2000; 165:6703-9.);

Details

Origin ID

C103890;

UMLS CUI

C3641673;

OMIM relation
- Tumor necrosis factor receptor superfamily, member 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
- TNFRSF8 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Extracellular Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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