Tumor Necrosis Factor Receptor Superfamily Member 6B

Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 6B;

NCIt synonyms : TR6; TNFRSF6B; M68; Decoy Receptor 3; DCR3; Decoy Receptor for FAS Ligand; FAS Ligand Decoy Receptor;

NCIt definition : Tumor necrosis factor receptor superfamily member 6B (300 aa, 33 kDa) is encoded by the human TNFRSF6B gene. This protein plays a role in the inhibition of apoptosis.;

NCIt note : Expressed in stomach, spinal cord, lymph node, trachea, spleen, colon and lung, human TNFRSF6B Gene (TNFR Family) encodes isoforms of 300-aa 33-kDa (precursor) secreted Decoy Receptor for FAS Ligand, a decoy receptor containing 4 TNFR-Cys repeats that protects against apoptosis by competing with death receptors for cytotoxic ligands TNFS14 and FasL.;

Details

Origin ID

C30112;

UMLS CUI

C1259595;

OMIM relation
- Tumor necrosis factor receptor superfamily, member 6b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TNFRSF6B protein, human [MeSH Supplementary Concept]
- TNFRSF6B protein, human [MeSH concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
- TNFRSF6B Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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