Lexatumumab - CISMeF

Preferred Label : Lexatumumab;

NCIt synonyms : Monoclonal Antibody HGS-ETR2; Anti-TRAIL Receptor 2 Monoclonal Antibody HGS-ETR2;

NCIt related terms : anti-TRAIL R2 mAb HGS-ETR2;

NCIt definition : A fully human monoclonal agonistic antibody directed against tumor necrosis factor-alpha (TNF-alpha)-related apoptosis-inducing ligand receptor-2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural ligand TRAIL, lexatumumab binds to and activates TRAIL-R2, which may trigger apoptosis in and inhibit the growth of TRAIL-R2-expressing tumor cells. TRAIL-R2, also known as death receptor 5 (DR5), is a member of the TNF receptor family and is expressed on many malignant cell types.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL-R2 on the surface of some tumor cells, which may kill the tumor cells. HGS-ETR2 is a type of monoclonal antibody.;

UNII : 967Q0SJD77;

CAS number : 845816-02-6;

Molecule name : HGS-ETR2; HGS1018;

Codes from synonyms : CDR0000537263; CDR0000641121; CDR0000643597;

Details

Origin ID

C64621;

UMLS CUI

C1721684;

Currated CISMeF NLP mapping
- lexatumumab [MeSH concept]
- lexatumumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- lexatumumab [MeSH concept]
- lexatumumab [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]

Keyword's position in hierarchy(ies) :

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