Preferred Label : Anti-CEA/Anti-DR5 Bispecific Antibody IBI3004;
NCIt synonyms : CEA x DR5 Bispecific Antibody IBI3004; Anti-CEA/DR5 Bispecific Antibody IBI3004; Anti-DR5/CEA Bispecific Antibody IBI3004;
NCIt definition : A bispecific antibody targeting both the tumor-associated antigen (TAA) carcinoembryonic
antigen-related cell adhesion molecule 5 (CEACAM5; CEA) and the pro-apoptotic death
receptor tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor
2 (TRAILR2; death receptor 5; DR5), with potential pro-apoptotic and antineoplastic
activities. Upon administration, anti-CEA/anti-DR5 bispecific antibody IBI3004 targets
and binds to both CEA and DR5 expressed on tumor cells. Receptor clustering and activation
of DR5 induces apoptosis in CEA-expressing tumor cells. Activation of DR5 plays a
key role in the induction of apoptosis. CEA-dependent clustering of DR5 allows IBI3004
to selectively induce apoptosis in CEA-expressing tumor cells thereby increasing efficacy
and decreasing toxicity. CEA is overexpressed by a variety of cancer cell types and
plays a key role in cell migration, cell invasion, and cell adhesion.;
Molecule name : IBI 3004; IBI-3004;
NCI Metathesaurus CUI : CL1928599;
Origin ID : C206265;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
