Preferred Label : Anti-DR5 Agonistic Monoclonal Antibody IGM-8444;
NCIt synonyms : Anti-DR5 Monoclonal Antibody IGM-8444; DR5 Agonist Antibody IGM-8444;
NCIt related terms : IGM-8444;
NCIt definition : A recombinant agonistic pentameric immunoglobulin M (IgM) monoclonal antibody directed
against human death receptor type 5 (DR5), also called tumor necrosis factor (TNF)-related
apoptosis-inducing ligand (TRAIL) receptor 2 (TRAILR2), with potential pro-apoptotic
and antineoplastic activities. Upon administration, anti-DR5 agonistic monoclonal
antibody IGM-8444, containing ten binding sites specific for DR5, specifically targets
and binds to DR5, which mimics the interaction of DR5 with its natural ligand TRAIL.
This cross-links and activates DR5 receptors, and activates the death receptor signaling
pathway. This results in the activation of caspase cascades, the induction of tumor
cell apoptosis and a reduction in proliferation of DR5-expressing tumor cells. DR5,
a member of the TNF receptor superfamily (TNFRSF), is expressed on the surfaces of
a variety of tumor cells and plays a key role in the induction of tumor cell apoptosis.;
UNII : 4JZ0485VXV;
Molecule name : IGM-8444; IGM 8444;
NCI Metathesaurus CUI : CL1642671;
Origin ID : C176625;
UMLS CUI : C5447332;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
