Preferred Label : Aplitabart;
NCIt synonyms : Anti-DR5 Monoclonal Antibody IGM-8444; DR5 Agonist Antibody IGM-8444; Anti-DR5 Agonistic Monoclonal Antibody IGM-8444;
NCIt definition : A recombinant agonistic pentameric immunoglobulin M (IgM) monoclonal antibody directed
against human death receptor type 5 (DR5), also called tumor necrosis factor (TNF)-related
apoptosis-inducing ligand (TRAIL) receptor 2 (TRAILR2), with potential pro-apoptotic
and antineoplastic activities. Upon administration, aplitabart, containing ten binding
sites specific for DR5, specifically targets and binds to DR5, which mimics the interaction
of DR5 with its natural ligand TRAIL. This cross-links and activates DR5 receptors,
and activates the death receptor signaling pathway. This results in the activation
of caspase cascades, the induction of tumor cell apoptosis and a reduction in proliferation
of DR5-expressing tumor cells. DR5, a member of the TNF receptor superfamily (TNFRSF),
is expressed on the surfaces of a variety of tumor cells and plays a key role in the
induction of tumor cell apoptosis.;
UNII : 4JZ0485VXV;
CAS number : 2796349-94-3;
Molecule name : IGM-8444; IGM 8444;
NCI Metathesaurus CUI : CL1642671;
Origin ID : C176625;
UMLS CUI : C5447332;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
