NCIt definition : A fully human monoclonal antibody directed against human death receptor 5 (DR5; TRAIL-R2;
TNFRSF10B) with potential pro-apoptotic and antineoplastic activities. Mimicking the
natural ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand), apomab
binds to DR5, which may directly activate the extrinsic apoptosis pathway and indirectly
induce the intrinsic apoptosis pathway in tumor cells. DR5 is a cell surface receptor
of the TNF-receptor superfamily and is expressed in a broad range of cancers.;
UNII : 703KLX5LXZ;
CAS number : 1108170-71-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1108170-71-3
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