Apoptosis-Inducing Factor 1, Mitochondrial

Preferred Label : Apoptosis-Inducing Factor 1, Mitochondrial;

NCIt synonyms : Apoptosis-Inducing Factor 1; Testicular Secretory Protein Li 4; Striatal Apoptosis-Inducing Factor; EC 1.6.99.-; AIF; AIFM1; Programmed Cell Death Protein 8;

NCIt definition : Apoptosis-inducing factor 1, mitochondrial (613 aa, 67 kDa) is encoded by the human AIFM1 gene. This protein plays a role in oxidation/reduction of NADH and nuclear disassembly in apoptotic cells.;

NCIt note : Apoptosis-inducing factor 1, mitochondrial (AIF) undergoes proteolytic processing following translocation into the mitochondrial intermembrane space, which results in the formation of an inner-membrane-anchored mature form (AIFmit). In response to apoptotic stimuli, AIFmit is further proteolytically processed into a soluble form (AIFsol), which migrates from the mitochondrion to the cytosol and translocates into the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. (UniProt);

Details

Origin ID

C178200;

UMLS CUI

C1530805;

Automatic exact mappings (from CISMeF team)
- Apoptosis-inducing factor, mitochondria-associated, 1 [OMIM gene]
- apoptosis inducing factor [MeSH Descriptor]
- apoptosis inducing factor mitochondria associated 1 [ORDO Gene]
OMIM relation
- Apoptosis-inducing factor, mitochondria-associated, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AIFM1 protein, human [MeSH Supplementary Concept]
- AIFM1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AIFM1 Gene [NCIt concept]
- Apoptosis Regulation Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Inner Mitochondrial Membrane [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Mitochondrial Import Sequence [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- AIF Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Caspase Activation [NCIt concept]
- Caspase-Independent Apoptosis [NCIt concept]
- Cell Respiration [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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