apoptosis inducing factor

Preferred Label : apoptosis inducing factor;

MeSH definition : A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.;

MeSH synonym : aif apoptosis regulatory protein; apoptosis-inducing factor, mitochondrial; mitochondrial apoptosis inducing factor; mitochondrial apoptosis-inducing factor; Apoptosis-Inducing factor;

CISMeF acronym : AIF;

MeSH annotation : INHIBITOR OF APOPTOSIS PROTEINS is also available;

Wikipedia link : https://en.wikipedia.org/wiki/Apoptosis inducing factor;

Is substance : O;

Details

Origin ID

D051033;

UMLS CUI

C0763396;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- apoptosis inducing factor [MeSH concept]
Related MeSH Supplementary Concept(s)
- AIFM1 protein, human [MeSH Supplementary Concept]
- AIFM1 protein, mouse [MeSH Supplementary Concept]
- Aifm1 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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