TNFRSF10B wt Allele

Preferred Label : TNFRSF10B wt Allele;

NCIt synonyms : ZTNFR9; TRICK2A; TRAILR2; Tumor Necrosis Factor Receptor Superfamily, Member 10B wt Allele; TRICKB; TRICK2B; DR5; KILLER/DR5; TRICK2; KILLER; TRAIL-R2; CD262; UNQ160/PRO186;

NCIt definition : Human TNFRSF10B wild-type allele is located within 8p22-p21 and is approximately 49 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 10B protein, plays a role in tumor necrosis factor-related apoptosis signal mediation.;

NCIt note : Head and neck squamous cell carcinoma may be linked to a 2-bp insertion in the TNFRSF10B gene at residue 1065, which introduces a premature stop codon and results in a truncated protein. (OMIM);

GenBank Accession Number : NM_003842;

Details

Origin ID

C51378;

UMLS CUI

C1705132;

OMIM relation
- Tumor necrosis factor receptor superfamily, member 10b [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 8p22-p21 [NCIt concept]
gene_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Caspase Activation [NCIt concept]
- Cell Death Signaling Process [NCIt concept]
- Cell Survival [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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