Huntingtin-Interacting Protein 1

Preferred Label : Huntingtin-Interacting Protein 1;

NCIt synonyms : HIP-1; HIP1; Huntingtin-Interacting Protein I; HIP-I;

NCIt definition : Huntingtin-interacting protein 1 (1037 aa, 116 kDa) is encoded by the human HIP1 gene. This protein plays a role in both clathrin-coat assembly and endocytosis.;

NCIt note : The affinity of huntingtin-interacting protein 1 for huntingtin is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease. (UniProt);

Details

Origin ID

C97539;

UMLS CUI

C0121811;

OMIM relation
- Huntingtin-interacting protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HIP1 protein, human [MeSH Supplementary Concept]
- HIP1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HIP1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Coated Vesicle [NCIt concept]
- Golgi Apparatus [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
gene_product_is_element_in_pathway
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Caspase Activation [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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