NLR Family CARD Domain-Containing Protein 4

Preferred Label : NLR Family CARD Domain-Containing Protein 4;

NCIt synonyms : Ipaf; Caspase Recruitment Domain-Containing Protein 12; ICE-Protease Activating Factor; Clan Protein; Ice Protease-Activating Factor; NLRC4; CARD, LRR, And NACHT-Containing Protein;

NCIt definition : NLR family CARD domain-containing protein 4 (1024 aa, 116 kDa) is encoded by the human NLRC4 gene. This protein is involved in the positive regulation of caspase activation, cytokine expression and pyroptosis of macrophages.;

NCIt note : There are at least 4 isoforms of the NLR family CARD domain-containing protein 4 produced by alternative splicing of the NLRC1 gene. (UniProt);

Details

Origin ID

C175712;

UMLS CUI

C5444337;

Automatic exact mappings (from CISMeF team)
- NLR family CARD domain containing 4 [ORDO Gene]
- Nlr family, caspase recruitment domain-containing 4 [OMIM gene]
OMIM relation
- Nlr family, caspase recruitment domain-containing 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- NLRC4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Winged Helix [NCIt concept]
gene_product_is_element_in_pathway
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Caspase Activation [NCIt concept]
- Immune System Process [NCIt concept]
- Immunity [NCIt concept]
- Inflammatory Response [NCIt concept]

Keyword's position in hierarchy(ies) :

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