Interleukin-1 Receptor-Associated Kinase-Like 2

Preferred Label : Interleukin-1 Receptor-Associated Kinase-Like 2;

NCIt synonyms : IRAK-2; IRAK2; Interleukin-1 Receptor-Associated Kinase 2; Interleukin-1 Receptor-Associated Kinase-2;

NCIt definition : Interleukin-1 receptor-associated kinase-like 2 (625 aa, 70 kDa) is encoded by the human IRAK2 gene. This protein is involved in signaling.;

NCIt note : Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This protein has been shown to be catalytically inactive. (UniProt);

Details

Origin ID

C29749;

UMLS CUI

C5441776;

Currated CISMeF NLP mapping
- Interleukin-1 Receptor-Associated kinase 2 [MeSH concept]
OMIM relation
- Interleukin 1 receptor-associated kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Interleukin-1 Receptor-Associated kinase 2 [MeSH concept]
gene_encodes_gene_product
- IRAK2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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