" /> Interleukin-1 Receptor-Associated Kinase 3 - CISMeF





Preferred Label : Interleukin-1 Receptor-Associated Kinase 3;

NCIt synonyms : IRAKM; IRAK3; Interleukin-1 Receptor-Associated Kinase M; Interleukin 1 Receptor-Associated Kinase M; Interleukin-1 Receptor-Associated Kinase-3; IRAK-M; EC 2.7.11.1; IRAK-3; Interleukin 1 Receptor-Associated Kinase 3; IL-1 Receptor-Associated Kinase M;

NCIt definition : Interleukin-1 receptor-associated kinase 3 (596 aa, 68 kDa) is encoded by the human IRAK3 gene. This protein plays a role in the negative regulation of toll-like receptor signaling;

NCIt note : IRAK3 appears to activate NF-kappa-B via IL1R. IRAK3 interacts with MYD88 and TRAF6 signaling proteins in a manner similar to the other IRAKs. It prevents dissociation of IRAK and IRAK4 from MYD88 and formation of IRAK/TRAF6 complexes.;

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29/04/2024


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