Th2 Cytokine Gene Induction Pathway

Preferred Label : Th2 Cytokine Gene Induction Pathway;

NCIt related terms : GATA3 participate in activating the Th2 cytokine genes expression;

Alternative definition : BIOCARTA: CD4 helper T cells differentiate into distinct subtypes, Th1 and Th2. Th2 cells are involved in the response to extracellular helminth parasites and allergic responses and secrete a distinct set of cytokines including IL-4, IL-5 and IL-13. The development and differentiation of T cells is influenced by many factors, including transcription factors such as GATA-3, a transcription factor associated with induction of Th2 cells. Factors that increase cAMP levels in Th2 cells activate p38 kinase, which phosphorylates and activates GATA-3 independently of PKA. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. These cytokines are found in a gene cluster together and are regulated coordinately by GATA-3. Binding of GATA-3 in the regulatory regions of these genes alters chromatin structure, increasing accessibility to other transcription factors. Activation of the T cell receptor through interaction with antigen on antigen presenting cells activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Dominant negative GATA-3 can repress the secretion of these cytokines and block the airway inflammation that causes asthma. Blocking GATA-3 action such as through antisense treatment has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_GATA3pathway;

Details

Origin ID

C39090;

UMLS CUI

C1515340;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- Interleukin-13 [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-5 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Trans-Acting T-Cell-Specific Transcription Factor GATA-3 [NCIt concept]
- Transcription Factor Jun-B [NCIt concept]
- Transcription Factor Maf [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit [NCIt concept]
- cAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit [NCIt concept]
pathway_has_gene_element
- IL13 wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL5 wt Allele [NCIt concept]
- JUNB wt Allele [NCIt concept]
- MAF wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKAR1A wt Allele [NCIt concept]
- PRKAR2A wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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