HMGN1 wt Allele

Preferred Label : HMGN1 wt Allele;

NCIt synonyms : HMG14; High-Mobility Group Nucleosome Binding Domain 1 wt Allele;

NCIt definition : Human HMGN1 wild-type allele is located in the vicinity of 21q22.2 and is approximately 7 kb in length. This allele, which encodes nonhistone chromosomal protein HMG-14 protein, is involved in the modulation of chromatin modifications. The HMGN1 gene is overexpressed in Down syndrome.;

NCIt note : The HMGN1 gene may play a role in the epigenetic regulation of gene expression. This gene has also been proposed to be involved in chromatin remodeling during embryogenesis. In mice, nonhistone chromosomal protein HMG-14 protein optimizes the cellular response to ionizing radiation and to other tumorigenic events.;

GenBank Accession Number : NM_004965;

Details

Origin ID

C52079;

UMLS CUI

C1705023;

OMIM relation
- High mobility group nucleosomal binding protein 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 21: 39642835-39636112 [NCIt concept]
gene_in_chromosomal_location
- 21q22.2 [NCIt concept]
gene_is_element_in_pathway
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_plays_role_in_process
- Chromatin Remodeling [NCIt concept]
- DNA Binding [NCIt concept]
- Transcription [NCIt concept]
- Transcription Elongation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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