" /> CHK1 Inhibitor MK-8776 - CISMeF





Preferred Label : CHK1 Inhibitor MK-8776;

NCIt synonyms : CHK1 Inhibitor SCH 900776; (R)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;

NCIt related terms : MK-8776;

NCIt definition : An agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor MK-8776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest.;

UNII : K2ZSF0992C;

InChIKey : GMIZZEXBPRLVIV-SECBINFHSA-N;

CAS number : 891494-63-6;

Molecule name : SCH 900776; SCH-900776; MK8776;

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03/07/2025


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