Chk1 Inhibitor SRA737

Preferred Label : Chk1 Inhibitor SRA737;

NCIt synonyms : Checkpoint Kinase 1 Inhibitor CCT245737; (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile; Chk1 Inhibitor CCT245737;

NCIt related terms : SRA-737;

NCIt definition : An orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral administration, chk1 inhibitor SRA737 selectively binds to chk1, thereby preventing chk1 activity and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. SRA737 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, an adenosine triphosphate (ATP)-dependent serine/threonine kinase overexpressed in a variety of cancer cell types, mediates cell cycle checkpoint control and is essential for DNA repair; it plays a key role in resistance to chemotherapeutic agents by repairing DNA damage.;

UNII : QB6LNL4NF6;

CAS number : 1489389-18-5;

Molecule name : CCT245737; SRA 737; PNT-737; SRA-737;

NCI Metathesaurus CUI : CL512598;

Details

Origin ID

C129580;

UMLS CUI

C4705167;

Currated CISMeF NLP mapping
- CCT245737 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CCT245737 [MeSH Supplementary Concept]
- SRA737 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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