" /> Prexasertib - CISMeF





Preferred Label : Prexasertib;

NCIt synonyms : 2-Pyrazinecarbonitrile, 5-((5-(2-(3-Aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)-;

NCIt definition : An inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, prexasertib selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA and may promote genomic instability and apoptosis. Prexasertib may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, a serine/threonine kinase, mediates cell cycle checkpoint control and is essential for DNA repair and plays a key role in resistance to chemotherapeutic agents.;

UNII : 820NH671E6;

InChIKey : DOTGPNHGTYJDEP-UHFFFAOYSA-N;

CAS number : 1234015-52-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1234015-52-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LY2606368; ACR 368; ACR-368;

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11/05/2024


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