Preferred Label : Chk1 Inhibitor LY2880070;
NCIt synonyms : Checkpoint Kinase 1 Inhibitor LY2880070;
NCIt related terms : LY-2880070;
NCIt definition : An orally bioavailable, selective, adenosine triphosphate (ATP)-competitive inhibitor
of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization
activities. Upon oral administration, chk1 inhibitor LY2880070 selectively binds to
chk1, thereby preventing chk1 activity and abrogating the repair of damaged DNA. This
may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction
of apoptosis. LY2880070 may potentiate the cytotoxicity of DNA-damaging agents and
reverse tumor cell resistance to chemotherapeutic agents. Chk1, an ATP-dependent serine/threonine
kinase overexpressed in a variety of cancer cell types, mediates cell cycle checkpoint
control and is essential for DNA repair; it plays a key role in resistance to chemotherapeutic
agents by repairing DNA damage.;
UNII : 33ZXE3519Y;
CAS number : 1375637-35-6;
Molecule name : ESP 01; ESP-01; LY-2880070; LY 2880070;
NCI Metathesaurus CUI : CL1778884;
Origin ID : C186473;
UMLS CUI : C4733491;
Semantic type(s)
- concept_is_in_subset
- has_target
