Preferred Label : CHK1 Inhibitor PF-477736;
NCIt related terms : PF-477736;
NCIt definition : A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential
chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent
serine-threonine kinase that is a key component in the DNA replication-monitoring
S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging
agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor
efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint
defects.;
UNII : XO23PGZ0SM;
CAS number : 952021-60-2;
Molecule name : PF-00477736; PF-477736;
Origin ID : C68820;
UMLS CUI : C4049082;
Semantic type(s)
- concept_is_in_subset
- has_target
