Preferred Label : Liposomal Chk1 Inhibitor SMP-3124 SMP-3124LP;
NCIt synonyms : Liposomal SMP3124; Liposomal SMP-3124; Liposomal Chk1 Inhibitor SMP-3124; Liposomal SMP 3124;
NCIt definition : A liposomal formulation containing an inhibitor of checkpoint kinase 1 (chk1), with
potential antineoplastic and chemosensitization activities. Upon administration of
liposomal chk1 inhibitor SMP-3124 SMP-3124LP, SMP-3124 selectively targets and binds
to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged
DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest,
and induction of apoptosis. Chk1, an ATP-dependent serine/threonine kinase, is activated
by DNA damage response and mediates cell cycle checkpoint control. It is essential
for DNA repair and plays a key role in resistance to chemotherapeutic agents.;
Molecule name : SMP 3124LP; SMP-3124LP;
Origin ID : C208343;
concept_is_in_subset
- has_target
