NCIt definition : An orally bioavailable inhibitor of checkpoint kinase 2 (chk2), with potential antineoplastic
and chemopotentiating activities. Upon oral administration, Chk2 inhibitor PHI-101
binds to and inhibits the activity of chk2, which may prevent the repair of DNA damage
caused by DNA-damaging agents. This may result in tumor cell apoptosis and potentiate
the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent
serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint
system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed
by a variety of cancer cell types.;
UNII : U2UY9TBQ8Z;
CAS number : 2127107-15-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2127107-15-5
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Semantic type(s)