" /> Lasmotinib - CISMeF





Preferred Label : Lasmotinib;

NCIt synonyms : Chk2 Inhibitor PHI-101;

NCIt definition : An orally bioavailable inhibitor of checkpoint kinase 2 (chk2), with potential antineoplastic and chemopotentiating activities. Upon oral administration, lasmotinib binds to and inhibits the activity of chk2, which may prevent the repair of DNA damage caused by DNA-damaging agents. This may result in tumor cell apoptosis and potentiate the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.;

UNII : U2UY9TBQ8Z;

CAS number : 2127107-15-5;

Molecule name : PHI 101; PHI-101;

NCI Metathesaurus CUI : CL1661912;

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09/08/2025


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