Preferred Label : Rabusertib;
NCIt synonyms : Checkpoint Kinase 2 Inhibitor LY2603618; 1-[5-bromo-4-methyl-2-S-(morpholin-2-yl-methoxy)-phenyl]-3-(5-methyl-pyrazin-2-yl)-urea; CHK2 Inhibitor LY2603618;
NCIt definition : An inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating
activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent
the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies
of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase,
is a key component in the DNA replication-monitoring checkpoint system and is activated
by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of
cancer cell types.;
UNII : 3S9L1NU6U7;
InChIKey : SYYBDNPGDKKJDU-ZDUSSCGKSA-N;
CAS number : 911222-45-2;
Molecule name : LY2603618;
Chemical formula : C18H22BrN5O3;
Origin ID : C81937;
UMLS CUI : C3642428;
Semantic type(s)
- concept_is_in_subset
- has_target
