" /> Belumosudil - CISMeF





Preferred Label : Belumosudil;

NCIt synonyms : ROCK-II Inhibitor KD025; 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide; Rho-associated Coiled-coil Kinase 2 Inhibitor KD025; ROCK2 Inhibitor KD025;

NCIt definition : An orally bioavailable inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II), with potential immunomodulating activity. Upon oral administration, belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signal transduction pathways and modulates various pro- and anti-inflammatory immune cell responses through the regulation of signal transducer and activator of transcription 3 and 5 (STAT3/STAT5) phosphorylation. This downregulates pro-inflammatory Th17 cells and increases regulatory T (Treg) cells. Belumosudil also inhibits ROCK2-mediated fibrotic processes, including stress fiber formation, myofibroblast activation and pro-fibrotic gene transcription. ROCK2 is upregulated in various diseases, including various fibrotic, neurodegenerative and autoimmune diseases.;

UNII : 834YJF89WO;

InChIKey : GKHIVNAUVKXIIY-UHFFFAOYSA-N;

CAS number : 911417-87-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 911417-87-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SLx 2119; KD 025; SLx-2119; KD-025;

NCI Metathesaurus CUI : CL509002;

Codes from synonyms : 29663;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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