Belumosudil - CISMeF

Preferred Label : Belumosudil;

NCIt synonyms : ROCK-II Inhibitor KD025; 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide; Rho-associated Coiled-coil Kinase 2 Inhibitor KD025; ROCK2 Inhibitor KD025;

NCIt definition : An orally bioavailable inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II), with potential immunomodulating activity. Upon oral administration, belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signal transduction pathways and modulates various pro- and anti-inflammatory immune cell responses through the regulation of signal transducer and activator of transcription 3 and 5 (STAT3/STAT5) phosphorylation. This downregulates pro-inflammatory Th17 cells and increases regulatory T (Treg) cells. Belumosudil also inhibits ROCK2-mediated fibrotic processes, including stress fiber formation, myofibroblast activation and pro-fibrotic gene transcription. ROCK2 is upregulated in various diseases, including various fibrotic, neurodegenerative and autoimmune diseases.;

UNII : 834YJF89WO;

InChIKey : GKHIVNAUVKXIIY-UHFFFAOYSA-N;

CAS number : 911417-87-3;

Molecule name : SLx 2119; KD 025; SLx-2119; KD-025;

NCI Metathesaurus CUI : CL509002;

Codes from synonyms : 29663;

Details

Origin ID

C128786;

UMLS CUI

C5418179;

Automatic exact mappings (from CISMeF team)
- KD025 [MeSH concept]
Currated CISMeF NLP mapping
- belumosudil [MeSH Supplementary Concept]
- belumosudil [MeSH concept]
False automatic mappings
- KD025 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Belumosudil (substance) [SNOMED CT concept]
- KD025 [MeSH Supplementary Concept]
- Product containing belumosudil (medicinal product) [SNOMED CT concept]
- belumosudil [MeSH Supplementary Concept]
- belumosudil [ATC Code]
Validated automatic mappings to BTNT
- belumosudil [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_salt_form
- Belumosudil Mesylate [NCIt concept]
has_target
- Rho-Associated Protein Kinase 2 [NCIt concept]
is_free_acid_or_base_form_of
- Belumosudil Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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