Protein Smoothened

Preferred Label : Protein Smoothened;

NCIt synonyms : SMOH; Smoothened; SMO; Gx Protein; Smoothened Homolog Protein; Protein Gx; Smoothened Homolog;

NCIt definition : Protein smoothened (787 aa, 86 kDa) is encoded by the human SMO gene. This protein plays a role in the modulation of hedgehog signaling pathways.;

NCIt note : Smoothened homolog (SMO) contains one frizzled domain that seems to form a complex with patched homologs (PTCH) to transduce the sonic hedgehog protein (SHH) signal. SHH binding to the PTCH receptor appears to relieve constitutive SMO repression by PTCH and to activate target gene transcription.;

Détails

Origin ID

C29980;

UMLS CUI

C1311076;

OMIM relation
- Smoothened, frizzled class receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SMO protein, human [MeSH Supplementary Concept]
- SMO protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- SMO Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cilium [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- SMO NP_005622.1:p.A374E [NCIt concept]
- SMO NP_005622.1:p.E518A [NCIt concept]
- SMO NP_005622.1:p.E518K [NCIt concept]
- SMO NP_005622.1:p.I408V [NCIt concept]
- SMO NP_005622.1:p.L221R [NCIt concept]
- SMO NP_005622.1:p.L412F [NCIt concept]
- SMO NP_005622.1:p.M525L [NCIt concept]
- SMO NP_005622.1:p.N219D [NCIt concept]
- SMO NP_005622.1:p.P641A [NCIt concept]
- SMO NP_005622.1:p.S533N [NCIt concept]
- SMO NP_005622.1:p.V321M [NCIt concept]
- SMO Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Frizzled Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Basal Cell Carcinoma Pathway [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- Sonic Hedgehog Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Glasdegib [NCIt concept]
- Glasdegib Maleate [NCIt concept]
- Patidegib [NCIt concept]
- Patidegib Topical Gel [NCIt concept]
- Smoothened Antagonist BMS-833923 [NCIt concept]
- Smoothened Antagonist LEQ506 [NCIt concept]
- Smoothened Antagonist TAK-441 [NCIt concept]
- Sonidegib [NCIt concept]
- Taladegib [NCIt concept]
- Vismodegib [NCIt concept]

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