NCIt definition : Protein smoothened (787 aa, 86 kDa) is encoded by the human SMO gene. This protein
plays a role in the modulation of hedgehog signaling pathways.;
NCIt note : Smoothened homolog (SMO) contains one frizzled domain that seems to form a complex
with patched homologs (PTCH) to transduce the sonic hedgehog protein (SHH) signal.
SHH binding to the PTCH receptor appears to relieve constitutive SMO repression by
PTCH and to activate target gene transcription.;
https://www.senat.fr/rap/r22-931/r22-931.html 2023 France technical report Supplies Base of the Prostate Shield Device Core Specimen Nicotine Measurement shield, nos Protein Smoothened Core Device Ethinyl Estradiol/Levonorgestrel nicotiana tabacum Dental Base Baseline Epoch Smoking Tobacco SMO wt Allele Nucleotide smoke nicotine New Lesion Identification Newar Language Tobacco Smoking smoke base, nos Nicotine Gum Baseline tobacco products Nicotine Lever Tobacco Smoke nicotine