NCIt definition : Smoothened homolog (787 aa, 86 kDa) is encoded by the human SMO gene. This protein
plays a role in the modulation of hedgehog signaling pathways.;
NCIt note : Smoothened homolog (SMO) contains one frizzled domain that seems to form a complex
with patched homologs (PTCH) to transduce the sonic hedgehog protein (SHH) signal.
SHH binding to the PTCH receptor appears to relieve constitutive SMO repression by
PTCH and to activate target gene transcription.;