Preferred Label : Smoothened Antagonist LEQ506;
NCIt related terms : NVP-LEQ-506;
NCIt definition : An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic
activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand
cell surface receptor Smo, which may result in the suppression of the Hh signaling
pathway, thereby inhibiting tumor cell growth. The Hh signaling pathway plays an important
role in cellular growth, differentiation and repair. Dysregulated activation of Hh
pathway signaling and uncontrolled cellular proliferation, as is observed in a variety
of cancers, may be associated with mutations in the Hh-ligand cell surface receptor
Smo.;
UNII : 6SJX1T5HJD;
CAS number : 1204975-42-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1204975-42-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : LEQ506;
NCI Metathesaurus CUI : CL421477;
Origin ID : C91089;
UMLS CUI : C2984030;
Semantic type(s)
- concept_is_in_subset
- has_target
