" /> Vismodegib - CISMeF





Preferred Label : Vismodegib;

NCIt synonyms : Hedgehog Antagonist GDC-0449; 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide;

NCIt related terms : GDC-0449;

NCIt definition : An orally bioavailable, small molecule inhibitor of SMO and the Hedgehog (Hh) pathway, with potential antineoplastic activity. Upon oral administration, vismodegib targets, binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of Hedgehog signaling pathway antagonist.;

UNII : 25X868M3DS;

InChIKey : BPQMGSKTAYIVFO-UHFFFAOYSA-N;

CAS number : 879085-55-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 879085-55-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Erivedge;

Molecule name : GDC-0449;

Chemical formula : C19H14Cl2N2O3S;

Codes from synonyms : CDR0000615496; 541;

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15/05/2024


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