Preferred Label : Taladegib;
NCIt synonyms : 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide; Benzamide, 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl)-4-piperidinyl)-2-(trifluoromethyl)-;
NCIt definition : An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell
surface receptor smoothened (Smo) with potential antineoplastic activity. Taladegib
inhibits signaling that is mediated by the Hh pathway protein Smo, which may result
in a suppression of the Hh signaling pathway and may lead to the inhibition of the
proliferation of tumor cells in which this pathway is abnormally activated. The Hh
signaling pathway plays an important role in cellular growth, differentiation and
repair; constitutive activation of this pathway is associated with uncontrolled cellular
proliferation and has been observed in a variety of cancers.;
UNII : QY8BWX1LJ5;
InChIKey : SZBGQDXLNMELTB-UHFFFAOYSA-N;
CAS number : 1258861-20-9;
Molecule name : LY-2940680;
Origin ID : C103826;
UMLS CUI : C4282368;
Semantic type(s)
- concept_is_in_subset
- has_target
