NCIt related terms : BMS-833923 DIMESYLATE MONOHYDRATE;
NCIt definition : An orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic
activity. SMO inhibitor BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein
SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein
coupled receptor that lies just downstream of the SHH ligand cell surface receptor
Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and
ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling
pathway plays an important role in cellular growth, differentiation and repair; constitutive
activation of this pathway is associated with uncontrolled cellular proliferation
and has been observed in a variety of cancers.;
Semantic type(s)