NCIt definition : An orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway
with potential antineoplastic activity. Specifically, patidegib binds to and inhibits
the cell membrane-spanning G-protein coupled receptor SMO, which may result in the
suppression of Hh pathway signaling and a decrease in tumor cell proliferation and
survival. SMO is activated upon binding of Hh ligand to the cell surface receptor
Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular
proliferation may be associated with SMO mutations. The Hh signaling pathway plays
an important role in proliferation of neuronal precursor cells in the developing cerebellum
and other tissues.;
UNII : JT96FPU35X;
InChIKey : HZLFFNCLTRVYJG-WWGOJCOQSA-N;
CAS number : 1037210-93-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1037210-93-7
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Automatic exact mappings (from CISMeF team)