Preferred Label : Patidegib Topical Gel;
NCIt synonyms : IPI-926 Topical Gel; Patidegib Gel;
NCIt definition : A topical gel containing patidegib, a cyclopamine-derived inhibitor of the Hedgehog
(Hh) pathway, with potential antineoplastic activity. Upon topical application of
the patidegib gel, patidegib binds to and inhibits the activity of the G-protein coupled
receptor smoothened (SMO), thereby inhibiting Hh pathway signaling. This decreases
proliferation and survival in tumor cells in which the Hh pathway is overactivated.
Upregulated Hh signaling is associated with uncontrolled tumor cell proliferation.
Topical application of patidegib allows for local anti-tumor activity while avoiding
systemic exposure and unwanted systemic effects.;
NCI Metathesaurus CUI : CL937835;
Origin ID : C158420;
UMLS CUI : C4764365;
Semantic type(s)
- concept_is_in_subset
- has_target
