Glasdegib Maleate

Preferred Label : Glasdegib Maleate;

NCIt synonyms : PF 04449913 Maleate; 1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea Maleate;

NCIt definition : The maleate salt form of glasdegib, an orally bioavailable small-molecule, smoothened (SMO) receptor inhibitor, with potential antineoplastic activity. Upon oral administration, glasdegib targets, binds to and inhibits the activity of SMO. This inhibits the activity of the Hedgehog (Hh) signaling pathway and inhibits the growth of tumor cells in which this pathway is aberrantly activated. SMO, a transmembrane protein, is involved in Hh signal transduction. The Hh signaling pathway plays an important role in cellular growth, differentiation, repair, and cancer stem cell (CSC) survival. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies and is associated with uncontrolled cellular proliferation in a variety of cancers.;

UNII : TH2EV99S4Z;

CAS number : 2030410-25-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2030410-25-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Daurismo;

NCI Metathesaurus CUI : CL935991;

Origin ID

C156894;

UMLS CUI

C4741340;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Glasdegib [NCIt concept]
has_target
- Smoothened Homolog [NCIt concept]
is_component_of_chemotherapy_regimen
- Low-dose Cytarabine/Glasdegib Regimen [NCIt concept]
is_salt_form_of
- Glasdegib [NCIt concept]

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