Preferred Label : Sonidegib;
NCIt synonyms : Smoothened Antagonist LDE225; (1,1'-Biphenyl)-3-carboxamide, N-(6-((2R,6S)-2,6-dimethyl-4-morpholinyl)-3-pyridinyl)-2-
methyl-4'-(trifluoromethoxy)-, rel-; Oral Smoothened Antagonist LDE225; Erismodegib;
NCIt definition : An orally bioavailable small-molecule smoothened (Smo) antagonist with potential antineoplastic
activity. Sonidegib selectively binds to the hedgehog (Hh)-ligand cell surface receptor
Smo, which may result in the suppression of the Hh signaling pathway and, so, the
inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling
pathway plays an important role in cellular growth, differentiation and repair. Inappropriate
activation of Hh pathway signaling and uncontrolled cellular proliferation, as is
observed in a variety of cancers, may be associated with mutations in the Hh-ligand
cell surface receptor Smo.;
UNII : 0RLU3VTK5M;
InChIKey : VZZJRYRQSPEMTK-CALCHBBNSA-N;
CAS number : 956697-53-3;
Drug name : Odomzo;
Molecule name : LDE-225; LDE 225;
Chemical formula : C26H26F3N3O3;
Codes from synonyms : 469;
Origin ID : C82385;
UMLS CUI : C3886731;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
