Ephrin Type-B Receptor 3

Preferred Label : Ephrin Type-B Receptor 3;

NCIt synonyms : EphB3 Protein; EPH-Like Tyrosine Kinase 2; EC 2.7.1.112; Tyrosine-Protein Kinase Receptor HEK-2; EPH-Like Tyrosine Kinase-2; Ephrin Receptor-EphB3; Human Embryo Kinase 2; EphB3; Tyrosine-Protein Kinase TYRO6; Ephrin Receptor EphB3; hEK2; Embryonic Kinase 2; EPH-Like Kinase 2; EC 2.7.10.1; EK2;

NCIt definition : Ephrin type-B receptor 3 (998 aa, 110 kDa) is encoded by the human EPHB3 gene. This protein plays a role in cell-cell signaling, tyrosine phosphorylation and central nervous system development.;

NCIt note : The signaling pathways downstream of ephrin receptors are referred to as forward signaling while the signaling pathways downstream of the ephrin ligands are referred to as reverse signaling. (UniProt);

Details

Origin ID

C26168;

UMLS CUI

C1333409;

OMIM relation
- Ephrin receptor ephb3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- EPHB3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Ephrin Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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