" /> Dihydropyrimidinase-Related Protein 5 - CISMeF





Preferred Label : Dihydropyrimidinase-Related Protein 5;

NCIt synonyms : CV2 Antigen; DPYSL5; CRMP3-Associated Molecule; Collapsin Response Mediator Protein-5; CRAM; UNC33-Like Phosphoprotein 6; ULIP-6; Collapsin Response Mediator Protein 5; DRP-5;

NCIt related terms : CRMP5; CV2;

NCIt definition : Dihydropyrimidinase-related protein 5 (564 aa, 61 kDa) is encoded by the human DPYSL5 gene. This protein is involved in the negative regulation of axonal and dendrite outgrowth.;

Alternative definition : CDISC: An antigen encoded by the DPYSL5 gene that regulates neurite outgrowth and neurogenesis. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative disorders related to cancer, such as paraneoplastic neurologic syndrome.;

NCIt note : Dihydropyrimidinase-related protein 5 is a target for autoantibodies in subjects with paraneoplastic neuropathy.; Dihydropyrimidinase-related protein 5 lacks most of the conserved residues that bind the metal cofactor necessary for dihydropyrimidinase activity. (UniProt);

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31/07/2025


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