NCIt definition : Dihydropyrimidinase-related protein 5 (564 aa, 61 kDa) is encoded by the human DPYSL5
gene. This protein is involved in the negative regulation of axonal and dendrite outgrowth.;
Alternative definition : CDISC: An antigen encoded by the DPYSL5 gene that regulates neurite outgrowth and
neurogenesis. It can be considered as a neuronal autoantigen and is commonly associated
with autoimmune neurodegenerative disorders related to cancer, such as paraneoplastic
neurologic syndrome.;
NCIt note : Dihydropyrimidinase-related protein 5 is a target for autoantibodies in subjects with
paraneoplastic neuropathy.; Dihydropyrimidinase-related protein 5 lacks most of the conserved residues that bind
the metal cofactor necessary for dihydropyrimidinase activity. (UniProt);