Ephrin Type-B Receptor 4

Preferred Label : Ephrin Type-B Receptor 4;

NCIt synonyms : EphB4; Ephrin Receptor EphB4; EC 2.7.10.1; Tyrosine-Protein Kinase Receptor HTK; Tyrosine-Protein Kinase TYRO11;

NCIt definition : Ephrin type-B receptor 4 (987 aa, 108 kDa) is encoded by the human EPHB4 gene. This protein plays a role in ephrin-B binding, tyrosine phosphorylation, and signal transduction.;

NCIt note : The signaling pathways downstream of ephrin receptors are referred to as forward signaling while the signaling pathways downstream of the ephrin ligands are referred to as reverse signaling. (UniProt);

Details

Origin ID

C113832;

UMLS CUI

C3810533;

Automatic exact mappings (from CISMeF team)
- EPH receptor B4 [ORDO Gene]
- Ephrin receptor ephb4 [OMIM gene]
OMIM relation
- Ephrin receptor ephb4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EPHB4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Ephrin Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
- Ephrin B Reverse Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Angiogenesis Inhibitor JI-101 [NCIt concept]
- Recombinant EphB4-HSA Fusion Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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