Preferred Label : Recombinant EphB4-HSA Fusion Protein;
NCIt synonyms : sEphB4-HSA;
NCIt definition : A recombinant fusion protein composed of the full-length extracellular domain (soluble)
of human receptor tyrosine kinase ephrin type-B receptor 4 (sEphB4) and fused, at
its C-terminus, to full-length human serum albumin (HSA), with potential antineoplastic
and anti-angiogenic activities. sEphB4-HSA functions as a decoy receptor for the membrane-bound
ligand Ephrin-B2 (Efnb2) and interferes with the binding of Efnb2 to its native receptors,
including EphB4 and EphA3. This may result in a reduction of angiogenesis and a reduction
in cell growth of Efnb2 and/or EphB4 over-expressing tumor cells. In addition, this
agent also prevents the angiogenic effects of numerous growth factors due to interactions
between Efnb2 and EphB4. Efnb2 and EphB4 are overexpressed in a variety of tumor cell
types; the bi-directional signaling of Efnb2-EphB4 plays an important role in angiogenesis
and tumor cell migration, invasion, and proliferation. Albumin reduces this agent's
degradation, improves circulation time and may thus improve efficacy.;
UNII : SO0RV2V6EJ;
NCI Metathesaurus CUI : CL436876;
Origin ID : C102569;
UMLS CUI : C3640822;
Semantic type(s)
- concept_is_in_subset
- has_target
