Ephrin Type-A Receptor 3

Preferred Label : Ephrin Type-A Receptor 3;

NCIt synonyms : Ephrin Receptor-EphA3; EPH-Like Tyrosine Kinase 1; HEK; Human Embryo Kinase 1; EPA3; Tyrosine Protein Kinase Receptor ETK1; EPHA3; Ephrin Receptor EphA3; Tyrosine-Protein Kinase TYRO4; Human Embryo Kinase; EC 2.7.10.1; Receptor Tyrosine Kinase HEK; EPH-Like Kinase 4; EK4; hEK4; TYRO4 Protein Tyrosine Kinase;

NCIt definition : Ephrin type-A receptor 3 (983 aa, 110 kDa) is encoded by the human EPHA3 gene. This protein is involved in cell-cell signaling, GTPase activity regulation and tyrosine phosphorylation.;

NCIt note : The signaling pathways downstream of ephrin receptors are referred to as forward signaling while the signaling pathways downstream of the ephrin ligands are referred to as reverse signaling. (UniProt);

Details

Origin ID

C17495;

UMLS CUI

C1452792;

OMIM relation
- Ephrin receptor epha3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- EPHA3 protein, human [MeSH concept]
- EPHA3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EPHA3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- EphA Receptor Family [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- Ephrin A Forward Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cellular Tropism [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Ifabotuzumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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